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Table of Contents
- What is Canadian Pharmacy Cialis?
- Cialis Mechanism of Action
- Cialis Effects
- Generic Cialis
- Cialis Dosage and Instructions for Use
- Cialis Side Effects
- Cialis Contraindications
- Cialis Interactions
- Tadalafil as a Cialis Active Substance
- Cialis Special Instructions for Different Groups of People
- Cialis Additional Information
- Cialis vs Viagra vs Levitra
- Why Canadian Pharmacy Cialis?
- Cialis FAQs
- Cialis Reviews
1. What is Canadian Pharmacy Cialis?
Cialis (Tadalafil) is an available and effective medication for treatment of male erectile dysfunction, i.e. the inability to achieve a proper erection necessary for a full sexual intercourse.
Cialis active ingredient: Tadalafil.
Auxiliary components: lactose monohydrate, lactose monohydrate, giproloza, giproloza, sodium lauryl sulfate, microcrystalline cellulose, croscarmellose sodium, magnesium stearate.
Canadian Health&Care Mall Cialis has a high efficiency and not only improves the quality of erection but also helps the patient recover the natural sexual relations. Canadian Cialis is reliable, efficient, easy to use and safe. The ED drug restores the normal sexual life of patients suffering from erectile dysfunction and makes forget about the constant thoughts about treatment.
2. Cialis Mechanism of Action
Canadian Cialis (Tadalafil) is a reversible inhibitor selectively acting on phosphodiesterase 5 (PDE5 inhibitor). The central role in erection management is played by relaxation of smooth muscle cells of the penis cavernosum bodies, which is locally triggered by acetylcholine, nitric oxide, and other physiological agents. Acetylcholine is produced by neurons of the parasympathetic nervous system, and the nitrogen oxide is released by non-adrenergic non-cholinergic neurons and endothelial cells. The effect is the suppression of the sympathetic nervous system state or alpha stimulation, which causes contraction of the smooth muscle cells.
Guanosine monophosphate (cGMP) and PDE5 play an important role for a normal erection. cGMF causes dilation of the arteries, improving blood flow to the erectile tissues. Blood vessels in the cavernous bodies are filling with blood, causing a decrease in the blood outflow from the penis and creating a blood pressure gradient – an erection. The enzyme PDE5 causes a decrease in the level of cGMP and terminates an erection. Canadian Cialis inhibits the action of PDE5, delaying the drop in the cGMP level. As a result, the cGMP level in the cavernous bodies allows men with erectile dysfunction have a normal erection.
3. Cialis Effects
Cialis is NOT A STIMULANT. Men need a natural sexual arousal and sexual stimulation of the penis for a successful result. That means, the process and the erection are natural. Cialis works precisely when it is necessary. The penis recovers its natural relaxed state just after the sexual act is completed
Canadian Health&Care Mall Cialis (Tadalafil) produces the following positive effects:
- Erection in general;
- The ability to achieve an erection needed for sexual intercourse;
- The ability to maintain an erection during sexual intercourse;
- Getting satisfaction from sexual intercourse;
- Positive emotions;
- Satisfaction from a good erection;
- Confidence in the ability to achieve and maintain an erection;
- Partner’s satisfaction from sexual intercourse.
4. Generic Cialis
Generic Cialis (Tadalafil) is a drug to increase potency and the analogue of brand Cialis. The drug takes effect in 30 minutes, its action lasts for 36-48 hours. Generic Cialis combines the quality and effectiveness of brand Cialis without extra expenses for the brand.
Generic Cialis price is low due to the fact that generic manufacturers do not need to spend huge amounts of money for the development of drugs and use a ready technology, as opposed to the pharmaceutical companies that developed the original drug. Besides, Generic Cialis cost in city pharmacies includes the added value (the staff salary, utilities and taxes).
Generics are preparations produced by different pharmaceutical companies. Their composition is identical to the original brand drug. In our case, Generic Cialis composition is identical to that of brand Cialis pills.
You may buy Generic Cialis online in Canadian Health and Care Mall. The medication is produced by the Indian pharmaceutical concern, which is the largest exporter of various pharmaceutical products in dozens of European countries.
5. Cialis Dosage and Instructions for Use
For oral administration only.
Cialis dosages available at Canadian HealthCare Mall – 2.5 mg, 5 mg, 10 mg, 20 mg, 40 mg, 50 mg, 60 mg, 100 mg, 200 mg.
Patients with frequent sexual activity (more than two times per week) are recommended Cialis normal dose 5 mg once a day in one and the same time, regardless of the meal. The daily Cialis dose can be reduced to 2.5 mg depending on the individual sensitivity.
Patients with infrequent sexual activity (at least twice a week) are recommended Cialis 20 mg once a day just prior to sexual activity, according to the drug instructions for use.
The maximum daily Cialis dose is 20 mg.
Single administration of Canadian Cialis (Tadalafil) in a dose of 500 mg in healthy men and patients with erectile dysfunction (repeatedly to 100 mg per day), Cialis side effects were the same as when using lower drug doses. Cialis overdose requires the standard symptomatic treatment. In hemodialysis, Tadalafil clearance is practically zero.
6. Cialis Side Effects
The most common Cialis side effects are headache and dyspepsia (11% and 7%, respectively). Adverse reactions associated with taking Canadian Health&Care Mall Cialis were generally mild or moderate in severity, transient and diminished with continued use of the drug. Other common Cialis side effects include back pain, myalgia, nasal congestion and redness of the face;
Rare side effects: edema of the eyelids, eye pain, conjunctival hyperemia, and dizziness;
Very rare side effects: hypersensitivity reactions (rash, urticaria and facial edema, Stevens-Johnson syndrome and exfoliative dermatitis); hypotension (in patients who take antihypertensive agents); hypertension, syncope; abdominal pain and gastroesophageal reflux disease; hyperhidrosis (excessive sweating); priapism erection and delay; blurred vision; ischemic optic neuropathy; retinal vein occlusion; eyesight violation;
One-off Cialis side effects: myocardial infarction, sudden cardiac death, stroke, chest pain, palpitations and tachycardia of patients who previously had cardiovascular risk factors. However, it is impossible to pinpoint whether these phenomena directly linked to these risk factors, Cialis, sexual arousal or a combination of these or other factors.
7. Cialis Contraindications
- Hypersensitivity to Tadalafil or to any ingredient of the drug;
- Administration of drugs containing any organic nitrates;
- Men under the age of 18;
- Contraindications to the sexual activity in patients with diseases of the cardiovascular system: myocardial infarction within the last 90 days, unstable stenocardia, stenocardia attack during sexual intercourse, chronic heart failure of II-IV class by NYHA classification, uncontrolled arrhythmias, hypotension (BP less than 90/50 mmHg), uncontrolled hypertension, ischemic stroke within the last 6 months;
- Loss of vision as a result of ischemic optic neuropathy (regardless of taking PDE-5 inhibitors, including Canadian Pharmacy Cialis);
- Simultaneous treatment with doxazosin, as well as drugs for erectile dysfunction treatment;
- Patients with chronic renal failure (creatinine clearance less than 30 mL / min) should take Cialis no more than twice per week;
- Lactose deficiency, lactose intolerance, glucose-galactose malabsorption.
8. Cialis Interactions
Do not take Cialis (Tadalafil) if you are taking nitrate medications such as nitroglycerin, isosorbide dinitrate, isosorbide mononitrate and others. Cialis interactions with any of these medications may cause very low pressure, which can lead to dizziness, fainting, heart attack, or heart attack.
Before taking Cialis (Tadalafil), inform your doctor if you are already taking any of the following medications:
- Other PDE5 inhibitors to treat impotence, such as Sildenafil (Viagra), Vardenafil (Levitra) and others;
- Erythromycin antibiotic (E-Mycin, Eryc, Ery-Tab);
- Antifungal drugs, such as itraconazole (Sporanox) or ketoconazole (Nizoral);
- HIV medicines such as indinavir (Crixivan), ritonavir (Norvir) and others.
If you are taking any of the drugs listed above, you need to adjust Cialis dosage or take the ED medicine under medical supervision.
9. Tadalafil as a Cialis Active Substance
Tadalafil (Cialis active ingredient) is an effective reversible selective inhibitor of specific phosphodiesterase type 5 (PDE5) of cyclic guanosine monophosphate (cGMP). When sexual stimulation causes local release of nitric oxide, inhibition of PDE5 by the substance leads to increased level of cGMP in the cavernous body of the penis. As a result, smooth muscles of arteries relax blood flow enters the tissues of the penis causing erections. Tadalafil has no effect is sexual stimulation and desire are absent.
Tadalafil does not change testosterone level, luteinizing and follicle-stimulating hormone in the blood plasma.
After oral administration, Tadalafil is rapidly absorbed. The rate and extent of Tadalafil absorption do not depend on meals, so Cialis may be taken without regard to meals. Besides, Cialis and alcohol are also compatible, but only in small doses of the latter.
Like other PDE5 inhibitors, Tadalafil has systemic vasodilator properties, which may lead to a transient decrease in blood pressure. Before taking Cialis, a physician should carefully consider whether the patients with cardiovascular diseases may have undesirable impact due to these vasodilator effects of the substance.
10. Cialis Special Instructions for Different Groups of People
Elderly patients
Healthy elderly (65 and over) patients have a lower Cialis clearance when taken orally, which is manifested through the increase in “concentration-time” relation by 25% if compared with healthy people aged 19 – 45. This difference is not clinically significant and does not require adjustment of Cialis dosage.
Patients with renal failure
Patients with renal insufficiency, including patients on hemodialysis, the “concentration-time” relation was higher than in healthy men.
Patients with hepatic insufficiency
The pharmacokinetics of Cialis in patients with mild and moderate hepatic impairment is comparable with that in healthy men. Patients with severe hepatic insufficiency (classified Child-Pugh Class C) require a medical consultation and Cialis dose adjustment.
Patients with diabetes mellitus
Patients with diabetes mellitus the “concentration-time” relation was smaller by 19% than that of healthy men when treated with Canadian Health&Care Mall Cialis. This difference does not require Cialis dose adjustment.
11. Cialis Additional Information
Cialis storage conditions:
Store at temperature between 59 and 86 degrees in the original packaging.
Keep out of the reach of children.
Effects on driving ability and work with the mechanisms:
No special requirements.
Use during pregnancy and breast-feeding period:
Cialis is not intended for women.
Cialis shelf life: 3 years.
Do not use the drug after the expiration date printed on the package.
12. Cialis vs Viagra vs Levitra
Cialis, Viagra and Levitra are the most effective drugs for erectile dysfunction treatment. Very often people ask which of these drugs is the best. The effect of each drug is slightly different from others. However, all three ED drugs require male sexual arousal for the best effect.
Action: Cialis has the longest action duration (36 hours), the second place in this comparison is given to Levitra with its 10-12 hours, and the third place is given to Viagra, the effect of which lasts 5-6 hours.
Meals: Viagra is recommended to be taken on an empty stomach, Cialis tablets work equally well regardless of the meal. The efficiency of Levitra may be slightly reduced after fatty foods consumption.
The advantage of all these drugs is a small amount of side effects. You should also know that individual organisms may require the use of a definite ED drug. The advantage of Cialis is its long action period, which allows to have sexual intercourse at any time during a day. No limitation in the time interval relieves emotional stress, promoting harmonious relations of sexual partners.
13. Why Canadian Pharmacy Cialis?
When you buy Cialis online from Canadian Health Care Mall, you have guaranteed:
-
Total confidentiality and privacy: You will never experience discomfort, awkwardness or embarrassment associated with the most sensitive issues of your intimate sphere. No passwords, no personal appearance – only assistance, rapid and adequate. When required, you will be able to communicate with our competent specialist; - The large assortment of generic products: Numerous products for different purposes can help you to eliminate every problem of your sexual life. Here you can buy generics online as well as big-name drugs capable to restore your erectile function and the process of ejaculation;
- The highest quality of products: We offer our the highest quality products, which help to achieve the desired result only. All products are certified and are perfectly safe for health when used correctly;
- Prompt delivery: You will not have to worry about Cialis delivery terms, as our courier will bring your order right to your door at the definite time!
- The personal approach to each client: Canadian Health&Care Mall never leaves our customers’ requests without attention. You will receive a prompt and detailed answer for each question!
- Cheap prices: Our online pharmacy has democratic price policy. Besides, we constantly offer promotional discounts and bonuses.
14. Cialis FAQs
“How effective is Cialis (Tadalafil)?”
Cialis pills are taken when needed, once a day. The drug improves erection of most men suffering from erectile dysfunction of any degree.
“Does Canadian Pharmacy Cialis cure serious erectile dysfunction cases?”
Yes. Clinical trials reveled that 81% of patients improved their potency after taking Cialis 20 mg. The study involved patients with various degrees of erectile dysfunction, from mild to severe.
“How fast is Cialis and how long can it work?”
Cialis takes effect within 16 minutes in some men. But most patients need 30 minutes. But remember, Erection will NOT occur without sexual stimulation. Cialis action lasts for about 36 hours after administration.
“I heard that Cialis is bad for the heart.”
Sexual activity is always a risk for men with heart diseases, so it is strongly recommended consulting a doctor before using the drug in this case.
“How often can I take Canadian Health&Care Mall Cialis?”
The recommended Cialis dose is 20 mg. The maximum recommended frequency of administration is once a day.
“What doctor may prescribe Cialis (Tadalafil)?”
A physician of any specialty can prescribe Cialis tablets, but the best variant is a urologist, a sexologist, an andrologist, an endocrinologist and a cardiologist.
“Canadian Pharmacy Cialis is safe and sold over the counter, isn’t it?”
Yes, clinical trials have proved the safety of Cialis. However, there are some Cialis interactions, especially with nitrates used in the treatment of heart diseases. In this case it is very important that Cialis are prescribed by a physician who has studied the patient’s medical history.
“Does Cialis effect on male fertility?”
Cialis has no effect on male fertility. However, Cialis may be useful in cases when erection violations interfere with conception.
“How effective is Cialis for women?”
Cialis is not indicated to solve sexual problems of women.
“Are there any age restrictions for taking Cialis?”
Cialis is not indicated for men under the age of 18.
“Is Cialis a natural (vegetable) or synthetic product?”
The active ingredient of Cialis is Tadalafil – a synthetic substance.
“Can Cialis help diabetes patients?”
Yes. Clinical trials showed that 68% of men with diabetes improved erection when treated with Cialis 20 mg.
“Are there any restrictions in foods while on Cialis?”
No. Cialis can be taken with or without food, so there is no need to change the patient ‘s regimen.
“Can I use Cialis on a daily basis for a long period?”
Daily use of the medication is NOT recommended.
“Can patients have an erection when they do not want it?”
No, Cialis requires sexual stimulation for the best results.
15. Cialis Reviews
Derick (39): “I take Cialis 2 months. There is a difference with Viagra, but not so big – Cialis contains Tadalafil, available without a doctor’s prescription. Don’t know whether the drug is available in usual pharmacies, as I order Cialis online on Canadian HealthCare Mall site. Tried other ED medications as well – the products are almost the same in fact, but I like personal approach here and no embarrassment.”
Nathan (52): “I was pleasantly surprised when bought Cialis from the online pharmacy, as well as my wife. But I do not share my little secret. Had a little
headache, which was gone just after analgin. No heart problems, no pressure jumps after Cialis pills – good medicine!”
Adam (44): “Cialis from Canadian Health and Care Mall turned out to be really reliable in helpful with women. I take it two or three hours before the date. When beginning to act, I feel a rush of blood to the face, a little stuffy nose, but eventually it all comes down to the genitals. Only a positive effect, the duration of a few days.”
George (31): “Recently I had a little misfire in bed. I was so scared! Really impotence? My doctor advised Cialis pills. The first signs of effect appeared after an hour and then everything went just fine, the action lasted until we fell asleep. Had a minor side effect – red cheeks and nasal congestion. Yes, had a slight headache, but everything was ok after painkiller medication. These minor troubles are nothing if compared to the result!”
Randal (56): “Cialis (Tadalafil) helped me forget about sexual problems after 50. I use it once a week on doctor’s advice, very happy with the result, the medicine is truly long-acting.”